Toxicological evaluation of Mojeaga herbal remedy on experimental animals

Abstract

This study evaluated the toxicological profile of Mojeaga herbal remedy on male and female animal models. In a time-dependent study, acute and chronic toxicity of Mojeaga herbal remedy in male and female Wistar rats were investigated through thorough examination of mortality rate, body and organ weight changes, hematological indexes, biomarkers of hepatic and renal functions, lipid profile, in-vivo antioxidant assay, hormonal assay and histopathological study across all treatment groups using standard protocol. No observable behavioral change with absent lethality at 10 to 10000 mg/kg of Mojeaga herbal remedy. There was no drastic significant change (p > 0.05) in the body and organ weight of the male and female animals. In the chronic toxicity studies, Mojeaga herbal remedy indicated no significant difference (p > 0.05) in haematological indices, liver function test, kidney function test, lipid profile, antioxidant indexes and hormonal assays with a slight significant increase (p < 0.05) in hepatic (ALT, ALP AST) and renal (potassium, sodium and chloride), lipid profile (cholesterol, triglyceride, high density lipoprotein, low density lipoprotein), in-vivo antioxidant assay (MOD, catalase, SOD and glutathione). Also, no defect on male and female hormonal assay (testosterone, estrogen, progesterone, follicle stimulating hormone and luteinizing hormone) activities among treated groups when compared with control. There was no marked significant toxicological effect (p > 0.05) on serum total protein (TP), blood urea nitrogen (BUN), albumin (ALB) and creatinine (CREA) urea levels across the whole treated groups at graded doses of 150, 300 and 600 mg/kg. Mojeaga product caused no histopathological variation on vital visceral organs (liver, kidney, heart, stomach, brain, lungs spleen testes and uterus) when compared with control. It is contingent from this study that Mojeaga herbal remedy exhibited bio-protective and hyper-stimulating effects with harmless and protective therapeutic benefits.